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Principal Investigator
Robert Raffai, Ph.D.
Assistant Professor of Surgery
Contact Information
SFVAMC (112G)
4150 Clement Street
San Francisco, CA 9412
Phone: (415) 750-2115
Fax: (415) 750-2181
4150 Clement Street
San Francisco, CA 9412
Phone: (415) 750-2115
Fax: (415) 750-2181
PublicationsEducation
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1986-90, McGill University Faculty of Medicine, Canada, B.Sc., Biochemistry
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1990-93, University of Montreal, Canada, Other, Biochemistry
- 1993-98, University of Ottawa, Canada, Ph.D., Biochemistry
Fellowships
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1997-01, J. David Gladstone Institutes, Postdoctoral Fellow, Mouse Models of Human Disease
- 2001-04, J. David Gladstone Institutes, Postdoctoral Fellow, Mouse Models of Human Disease
Selected Publications
- Raffai RL, Dong LM, Farese RV, Weisgraber KH. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci U S A. 98: 11587-91, Sep/25/2001.
- Raffai RL, Weisgraber KH. Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J Biol Chem. 277: 11064-8, Mar/29/2002.
- Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH. Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance. J Biol Chem. 278: 11670-5, Mar/28/2003.
- Raffai RL, Loeb SM, Weisgraber KH. Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arterioscler Thromb Vasc Biol. 25: 436-41, Feb/2005.
- Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 111: 3457-64, Jun/28/2005.
