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Liu M, Ng M, Phu T, Bouchareychas L, Feeley BT, Kim HT, Raffai RL, Liu X
Polarized macrophages regulate fibro/adipogenic progenitor (FAP) adipogenesis through exosomes.
Stem cell research & therapy, 2023-11-07.
Phu TA, Vu NK, Ng M, Gao AS, Stoolman JS, Chandel NS, Raffai RL
ApoE enhances mitochondrial metabolism via microRNA-142a/146a-regulated circuits that suppress hematopoiesis and inflammation in hyperlipidemia.
Cell reports, 2023-10-11.
Phu TA, Ng M, Vu NK, Gao AS, Raffai RL
ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia-driven hematopoiesis & inflammation via extracellular vesicles.
Journal of extracellular vesicles, 2023-08-01.
Fordjour FK, Abuelreich S, Hong X, Chatterjee E, Lallai V, Ng M, Saftics A, Deng F, Carnel-Amar N, Wakimoto H, Shimizu K, Bautista M, Phu TA, Vu NK, Geiger PC, Raffai RL, Fowler CD, Das S, Christenson LK, Jovanovic-Talisman T, Gould SJ
Exomap1 mouse: a transgenic model for in vivo studies of exosome biology.
bioRxiv : the preprint server for biology, 2023-05-29.
LaPlante EL, Stürchler A, Fullem R, Chen D, Starner AC, Esquivel E, Alsop E, Jackson AR, Ghiran I, Pereira G, Rozowsky J, Chang J, Gerstein MB, Alexander RP, Roth ME, Franklin JL, Coffey RJ, Raffai RL, Mansuy IM, Stavrakis S, deMello AJ, Laurent LC, Wang YT, Tsai CF, Liu T, Jones J, Van Keuren-Jensen K, Van Nostrand E, Mateescu B, Milosavljevic A
exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.
Cell genomics, 2023-04-20.
Lopez JL, Ramirez JL, Phu TA, Duong P, Bouchareychas L, Kuhrau CR, Lin PY, Eckalbar WL, Barczak AJ, Rudolph JD, Maliskova L, Conte MS, Vartanian SM, Raffai RL, Oskowitz AZ
Patients with abdominal aortic aneurysms have reduced levels of microRNA 122-5p in circulating exosomes.
PloS one, 2023-02-14.
Li G, Chen T, Dahlman J, Eniola-Adefeso L, Ghiran IC, Kurre P, Lam WA, Lang JK, Marb?n E, Mart?n P, Momma S, Moos M, Nelson DJ, Raffai RL, Ren X, Sluijter JPG, Stott SL, Vunjak-Novakovic G, Walker ND, Wang Z, Witwer KW, Yang PC, Lundberg MS, Ochocinska MJ, Wong R, Zhou G, Chan SY, Das S, Sundd P
Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.
Journal of extracellular vesicles, 2023-02-01.
Reitz KM, Althouse AD, Forman DE, Zuckerbraun BS, Vodovotz Y, Zamora R, Raffai RL, Hall DE, Tzeng E
MetfOrmin BenefIts Lower Extremities with Intermittent Claudication (MOBILE IC): randomized clinical trial protocol.
BMC cardiovascular disorders, 2023-01-21.
Mateescu B, Jones JC, Alexander RP, Alsop E, An JY, Asghari M, Boomgarden A, Bouchareychas L, Cayota A, Chang HC, Charest A, Chiu DT, Coffey RJ, Das S, De Hoff P, deMello A, D'Souza-Schorey C, Elashoff D, Eliato KR, Franklin JL, Galas DJ, Gerstein MB, Ghiran IH, Go DB, Gould S, Grogan TR, Higginbotham JN, Hladik F, Huang TJ, Huo X, Hutchins E, Jeppesen DK, Jovanovic-Talisman T, Kim BYS, Kim S, Kim KM, Kim Y, Kitchen RR, Knouse V, LaPlante EL, Lebrilla CB, Lee LJ, Lennon KM, Li G, Li F, Li T, Liu T, Liu Z, Maddox AL, McCarthy K, Meechoovet B, Maniya N, Meng Y, Milosavljevic A, Min BH, Morey A, Ng M, Nolan J, De Oliveira Junior GP, Paulaitis ME, Phu TA, Raffai RL, Reátegui E, Roth ME, Routenberg DA, Rozowsky J, Rufo J, Senapati S, Shachar S, Sharma H, Sood AK, Stavrakis S, Stürchler A, Tewari M, Tosar JP, Tucker-Schwartz AK, Turchinovich A, Valkov N, Van Keuren-Jensen K, Vickers KC, Vojtech L, Vreeland WN, Wang C, Wang K, Wang Z, Welsh JA, Witwer KW, Wong DTW, Xia J, Xie YH, Yang K, Zaborowski MP, Zhang C, Zhang Q, Zivkovic AM, Laurent LC
Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.
iScience, 2022-06-23.
Davies MR, Garcia S, Liu M, Chi H, Kim HT, Raffai RL, Liu X, Feeley BT
Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing.
The American journal of sports medicine, 2022-05-23.
Phu TA, Ng M, Vu NK, Bouchareychas L, Raffai RL
IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity.
Molecular therapy : the journal of the American Society of Gene Therapy, 2022-03-12.
Bittel M, Reichert P, Sarfati I, Dressel A, Leikam S, Uderhardt S, Stolzer I, Phu TA, Ng M, Vu NK, Tenzer S, Distler U, Wirtz S, Rothhammer V, Neurath MF, Raffai RL, Günther C, Momma S
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.
Journal of extracellular vesicles, 2021-10-01.
Bouchareychas L, Duong P, Phu TA, Alsop E, Meechoovet B, Reiman R, Ng M, Yamamoto R, Nakauchi H, Gasper WJ, Van Keuren-Jensen K, Raffai RL
High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.
iScience, 2021-07-10.
Duong P, Chung A, Bouchareychas L, Raffai RL
Correction: Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.
PloS one, 2020-07-23.
Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu TA, Chung A, Gomes M, Wong D, Meechoovet B, Capili A, Yamamoto R, Nakauchi H, McManus MT, Carpenter S, Van Keuren-Jensen K, Raffai RL
Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.
Cell reports, 2020-07-14.
Sorrentino TA, Duong P, Bouchareychas L, Chen M, Chung A, Schaller MS, Oskowitz A, Raffai RL, Conte MS
Circulating exosomes from patients with peripheral artery disease influence vascular cell migration and contain distinct microRNA cargo.
Journal of vascular surgery. Vascular science, 2020-02-28.
Murillo OD, Thistlethwaite W, Rozowsky J, Subramanian SL, Lucero R, Shah N, Jackson AR, Srinivasan S, Chung A, Laurent CD, Kitchen RR, Galeev T, Warrell J, Diao JA, Welsh JA, Hanspers K, Riutta A, Burgstaller-Muehlbacher S, Shah RV, Yeri A, Jenkins LM, Ahsen ME, Cordon-Cardo C, Dogra N, Gifford SM, Smith JT, Stolovitzky G, Tewari AK, Wunsch BH, Yadav KK, Danielson KM, Filant J, Moeller C, Nejad P, Paul A, Simonson B, Wong DK, Zhang X, Balaj L, Gandhi R, Sood AK, Alexander RP, Wang L, Wu C, Wong DTW, Galas DJ, Van Keuren-Jensen K, Patel T, Jones JC, Das S, Cheung KH, Pico AR, Su AI, Raffai RL, Laurent LC, Roth ME, Gerstein MB, Milosavljevic A
exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids.
Cell, 2019-04-04.
Das S
The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
Cell, 2019-04-04.
Srinivasan S, Yeri A, Cheah PS, Chung A, Danielson K, De Hoff P, Filant J, Laurent CD, Laurent LD, Magee R, Moeller C, Murthy VL, Nejad P, Paul A, Rigoutsos I, Rodosthenous R, Shah RV, Simonson B, To C, Wong D, Yan IK, Zhang X, Balaj L, Breakefield XO, Daaboul G, Gandhi R, Lapidus J, Londin E, Patel T, Raffai RL, Sood AK, Alexander RP, Das S, Laurent LC
Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation.
Cell, 2019-04-04.
Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Ming Wang J
Female Mice with Apolipoprotein E4 Domain Interaction Demonstrated Impairments in Spatial Learning and Memory Performance and Disruption of Hippocampal Cyto-Architecture.
Neurobiology of learning and memory, 2019-04-04.
Duong P, Chung A, Bouchareychas L, Raffai RL
Cushioned-Density Gradient Ultracentrifugation (C-DGUC) improves the isolation efficiency of extracellular vesicles.
PloS one, 2019-04-11.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanovic MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Line A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, et al
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Journal of extracellular vesicles, 2018-11-23.
Raffai RL
MicroRNA-146a & hematopoiesis: friend or foe in atherosclerosis.
Non-coding RNA investigation, 2018-07-17.
Bouchareychas L, Raffai RL
Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation.
Journal of cardiovascular development and disease, 2018-05-23.
Laura Bouchareychas,Allen Chung,David K Wong,Phat Duong,Robert L Raffai
Abstract 184: Hyperglycemia Enhances Pro-inflammatory Properties of Macrophage-derived Exosomes to Drive Hematopoiesis in Apolipoprotein E-deficient Mouse.
Arteriosclerosis Thrombosis and Vascular Biology, 2018-05-01.
Phat Duong,Allen Chung,David K Wong,Kang Li,King Y Hong,Laura Bouchareychas,Robert L Raffai
Abstract 443: Cushioned-Density Gradient Ultracentrifugation (C-DGUC) Improves the Isolation Efficiency of Exosomes for their use in Atherosclerosis Research.
Arteriosclerosis Thrombosis and Vascular Biology, 2018-05-01.
Laura Bouchareychas,Ryo Yamamoto,Fu Sang Luk,Roy Y Kim,David Wong,Jonathan Villeneuva,Phat Duong,Allen Chung,Hiromitsu Nakauchi,Robert Raffai
Abstract 408: ApoE Regulation of Hematopoiesis Suppresses Atherosclerosis by Reducing Adaptive Immunity in Hyperlipidemic Mice.
Arteriosclerosis Thrombosis and Vascular Biology, 2018-05-01.
Thomas A Sorrentino,Phat Duong,Laura Bouchareychas,Brian E Sansbury,Pete Mitchell,Mian Chen,Allen Chung,Melinda S Schaller,Matthew Spite,Robert L Raffai,Michael S Conte
Abstract 262: Circulating Exosomes from PAD Patients Modulate Vascular Repair and Inflammation.
Arteriosclerosis Thrombosis and Vascular Biology, 2018-05-01.
Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK
Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.
JCI insight, 2018-04-05.
Li K, Wong DK, Hong KY, Raffai RL
Cushioned-Density Gradient Ultracentrifugation (C-DGUC): A Refined and High Performance Method for the Isolation, Characterization, and Use of Exosomes.
Methods in molecular biology (Clifton, N.J.), 2018-01-01.
Li K, Wong DK, Luk FS, Kim RY, Raffai RL
Isolation of Plasma Lipoproteins as a Source of Extracellular RNA.
Methods in molecular biology (Clifton, N.J.), 2018-01-01.
Raffai R, Li K, Wong D, Hong J
Therapeutic control of systemic inflammation & atherosclerosis with ApoE-polarized macrophage exosomes.
Atherosclerosis, 2017-08-12.
Robert Raffai,Kang Li,David Wong,Justin Hong
Therapeutic control of systemic inflammation & atherosclerosis with ApoE-polarized macrophage exosomes.
Atherosclerosis, 2017-08-01.
Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ
Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model.
NMR in biomedicine, 2017-07-14.
Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH
An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury.
American journal of physiology. Renal physiology, 2017-03-22.
Cheung KH, Keerthikumar S, Roncaglia P, Subramanian SL, Roth ME, Samuel M, Anand S, Gangoda L, Gould S, Alexander R, Galas D, Gerstein MB, Hill AF, Kitchen RR, Lötvall J, Patel T, Procaccini DC, Quesenberry P, Rozowsky J, Raffai RL, Shypitsyna A, Su AI, Théry C, Vickers K, Wauben MH, Mathivanan S, Milosavljevic A, Laurent LC
Extending gene ontology in the context of extracellular RNA and vesicle communication.
Journal of biomedical semantics, 2016-04-12.
Tie G, Yan J, Messina JA, Raffai RL, Messina LM
Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells.
Journal of vascular research, 2016-04-01.
Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL
Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis.
Journal of cardiovascular pharmacology, 2016-01-01.
Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL
Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis.
Journal of cardiovascular pharmacology, Jan-2016;67(1):47-56.
View Abstract | PubMed AbstractPlus 
Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT
Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles, 2015-08-28.
Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S
Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.
Journal of extracellular vesicles, 2015-08-28.
Samuel O. Adeosun,Xu Hou,Xueying Zhao,Craig Stockmeier,Tom Mosley,Baoying Zheng,Robert Raffai,Qinli Zhang,Karl H. Weisgraber,Jun Ming Wang
Apolipoprotein e e4 domain interaction in size of hippocampal subregions, density of newborn neurons, and cognitive behaviors.
Alzheimer's & Dementia, 2015-07-01.
Li K, Ching D, Luk FS, Raffai RL
Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-?B-driven inflammation and atherosclerosis.
Circulation research, 2015-04-22.
Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT
Biogenesis, delivery, and function of extracellular RNA.
Journal of extracellular vesicles, 2015;[epublish]4:27494.
View Abstract | PubMed AbstractPlus 
Robert L. Raffai
Apolipoprotein E and Atherosclerosis: Beyond Lipid Effects.
, 2015-01-01.
Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Hepatology (Baltimore, Md.), 2014-11-24.
Wang G, Kim RY, Imhof I, Honbo N, Luk FS, Li K, Kumar N, Zhu BQ, Eberlé D, Ching D, Karliner JS, Raffai RL
The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction.
Journal of cardiovascular pharmacology, 2014-02-01.
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Stephens K, Raffai RL
Hyperglycemia impairs atherosclerosis regression in mice.
The American journal of pathology, Dec-2013;183(6):1981-92.  Epub 2013 Oct 8.
View Abstract | PubMed AbstractPlus 
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Stephens K, Raffai RL
Hyperglycemia impairs atherosclerosis regression in mice.
The American journal of pathology, 2013-10-08.
Eberlé D, Luk FS, Kim RY, Olivas VR, Kumar N, Posada JM, Li K, Gaudreault N, Rapp JH, Raffai RL
Inducible ApoE gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile.
Arteriosclerosis, thrombosis, and vascular biology, Aug-2013;33(8):1759-67.  Epub 2013 Jun 20.
View Abstract | PubMed AbstractPlus 
Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS
N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure.
PloS one, 2013-07-16.
Eberlé D, Luk FS, Kim RY, Olivas VR, Kumar N, Posada JM, Li K, Gaudreault N, Rapp JH, Raffai RL
Inducible ApoE gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile.
Arteriosclerosis, thrombosis, and vascular biology, 2013-06-20.
Raffai RL
Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis.
Current opinion in lipidology, 2012-10-01.
Raffai RL
Apolipoprotein E regulation of myeloid cell plasticity in atherosclerosis.
Current opinion in lipidology, Oct-2012;23(5):471-8.
View Abstract | PubMed AbstractPlus 
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Rapp JH, Raffai RL
Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.
PloS one, 2012-05-14.
Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS
A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.
PloS one, 2012-04-03.
Eberlé D, Kim RY, Luk FS, de Mochel NS, Gaudreault N, Olivas VR, Kumar N, Posada JM, Birkeland AC, Rapp JH, Raffai RL
Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice.
Arteriosclerosis, thrombosis, and vascular biology, 2012-03-22.
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Rapp JH, Raffai RL
Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.
PloS one, 2012;7(5):e35816.
View Abstract | PubMed AbstractPlus 
Gaudreault N, Kumar N, Posada JM, Stephens KB, Reyes de Mochel NS, Eberlé D, Olivas VR, Kim RY, Harms MJ, Johnson S, Messina LM, Rapp JH, Raffai RL
ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium.
Arteriosclerosis, thrombosis, and vascular biology, 2011-11-03.
Tie G, Yan J, Yang Y, Park BD, Messina JA, Raffai RL, Nowicki PT, Messina LM
Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
Journal of vascular research, 2010-04-30.
Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R
High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
American journal of physiology. Heart and circulatory physiology, 2010-01-08.
Tie G, Yan J, Yang Y, Park BD, Messina JA, Raffai RL, Nowicki PT, Messina LM
Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
Journal of vascular research, 2010;47(6):519-30.  Epub 2010 Apr 30.
View Abstract | PubMed AbstractPlus 
Carpenter B, Lin Y, Stoll S, Raffai RL, McCuskey R, Wang R
VEGF is crucial for the hepatic vascular development required for lipoprotein uptake.
Development (Cambridge, England), 2005-06-08.
Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.
Circulation, 2005-06-20.
Raffai RL, Loeb SM, Weisgraber KH
Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology, 2004-12-09.
Raffaï RL, McPherson R, Weisgraber KH, Innerarity TL, Rassart E, Bersot TP, Milne RW
Antibody phenotyping test for the human apolipoprotein E2 isoform.
Clinical chemistry, Sep-2003;49(9):1524-6.
Raffaï RL, McPherson R, Weisgraber KH, Innerarity TL, Rassart E, Bersot TP, Milne RW
Antibody phenotyping test for the human apolipoprotein E2 isoform.
Clinical chemistry, 2003-09-01.
Raffai RL, Weisgraber KH
Cholesterol: from heart attacks to Alzheimer's disease.
Journal of lipid research, 2003-07-01.
Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH
Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance.
The Journal of biological chemistry, 2003-01-27.
R. Raffai,S. Loeb,K. Weisgraber
3P-0878 A mouse model to study the role of ApoE in atherosclerosis regression and plaque vulnerability in peripheral arterial disease.
Atherosclerosis Supplements, 2003-01-01.
Raffai RL, Weisgraber KH
Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism.
The Journal of biological chemistry, 2002-01-15.
Raffaï RL
Periplasmic expression and purification of recombinant Fabs.
Methods in molecular biology (Clifton, N.J.), 2002-01-01.
Raffai RL, Dong LM, Farese RV, Weisgraber KH
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America, 2001-09-11.
Libeu CP, Lund-Katz S, Phillips MC, Wehrli S, Hernáiz MJ, Capila I, Linhardt RJ, Raffaï RL, Newhouse YM, Zhou F, Weisgraber KH
New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.
The Journal of biological chemistry, 2001-08-10.
Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R
Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling.
The Journal of biological chemistry, 2000-03-10.
Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R
Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling.
The Journal of biological chemistry, Mar-10-2000;275(10):7109-16.
View Abstract | PubMed AbstractPlus 
Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R
Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.
Protein expression and purification, 1999-06-01.
Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R
Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.
Protein expression and purification, Jun-1999;16(1):84-90.
View Abstract | PubMed AbstractPlus 
Trakhanov S, Parkin S, Raffaï R, Milne R, Newhouse YM, Weisgraber KH, Rupp B
Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A.
Acta crystallographica. Section D, Biological crystallography, 1999-01-01.
Raffai R, Maurice R, Weisgraber K, Innerarity T, Wang X, MacKenzie R, Hirama T, Watson D, Rassart E, Milne R
Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.
Journal of lipid research, Sep-1995;36(9):1905-18.
View Abstract | PubMed AbstractPlus 
Raffai R, Maurice R, Weisgraber K, Innerarity T, Wang X, MacKenzie R, Hirama T, Watson D, Rassart E, Milne R
Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.
Journal of lipid research, 1995-09-01.
R. Raffai¨,E. Rassart,K. Weisgraber,T. Innerarity,R. Milne
Determination of the fine specificity and molecular cloning of two monoclonal antibodies directed against the receptor-binding domain of human apolipoprotein E.
Atherosclerosis, 1994-09-01.
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