Atherosclerosis Research Lab »  Publications


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Gaudreault N, Kumar N, Posada JM, Stephens KB, Reyes de Mochel NS, Eberlé D, Olivas VR, Kim RY, Harms MJ, Johnson S, Messina LM, Rapp JH, Raffai RL
ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium.
Arteriosclerosis, thrombosis, and vascular biology, Feb-2012;32(2):264-72.  Epub 2011 Nov 3.
Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS
A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.
PloS one, 2012;7(4):e34177.
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Rapp JH, Raffai RL
Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice.
PloS one, 2012;7(5):e35816.
Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R
High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
American journal of physiology. Heart and circulatory physiology, Mar-2010;298(3):H1022-8.  Epub 2010 Jan 8.
Tie G, Yan J, Yang Y, Park BD, Messina JA, Raffai RL, Nowicki PT, Messina LM
Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
Journal of vascular research, 2010;47(6):519-30.  Epub 2010 Apr 30.
Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.
Circulation, Jun-28-2005;111(25):3457-64.  Epub 2005 Jun 20.
Raffai RL, Loeb SM, Weisgraber KH
Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology, Feb-2005;25(2):436-41.
Raffaï RL, McPherson R, Weisgraber KH, Innerarity TL, Rassart E, Bersot TP, Milne RW
Antibody phenotyping test for the human apolipoprotein E2 isoform.
Clinical chemistry, Sep-2003;49(9):1524-6.
Raffai RL, Weisgraber KH
Cholesterol: from heart attacks to Alzheimer's disease.
Journal of lipid research, Aug-2003;44(8):1423-30.
Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH
Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance.
The Journal of biological chemistry, Mar-28-2003;278(13):11670-5.
Raffai RL, Weisgraber KH
Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism.
The Journal of biological chemistry, Mar-29-2002;277(13):11064-8.
Raffai RL, Dong LM, Farese RV, Weisgraber KH
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America, Sep-25-2001;98(20):11587-91.
Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R
Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling.
The Journal of biological chemistry, Mar-10-2000;275(10):7109-16.
Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R
Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.
Protein expression and purification, Jun-1999;16(1):84-90.
Raffai R, Maurice R, Weisgraber K, Innerarity T, Wang X, MacKenzie R, Hirama T, Watson D, Rassart E, Milne R
Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.
Journal of lipid research, Sep-1995;36(9):1905-18.
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